University of Mangalore researchers say fruit fly could be an alternative animal model for research into gut disease

Recently, the incidence of IBD has increased rapidly in many Asian countries with a steady upward trend

Recently, the incidence of IBD has increased rapidly in many Asian countries with a steady upward trend

A study conducted by a team of researchers at the University of Mangalore revealed that a fruit fly (or fruit fly) could be used as an alternative animal model, rather than a mouse, for research into chronic and long-term inflammatory bowel diseases (IBD), characterized by inflammation of the gastrointestinal tract.

The international scientific journal on Biological Sciences, ‘3 Biotech’, published by Springer Nature, published their research work titled ‘Dextran sodium sulfate alters antioxidant status in the intestine affecting survival of Drosophila melanogaster’ on September 16, 2022.

The research team consists of Champrasad Varija Raghu, from the Department of Biotechnology – Ramalingaswamy Fellow in the University’s Department of Applied Zoology; Avinash Kudva, Scientific Officer, Department of Biochemistry, University; and graduate students Nishal Keshav, Ramyalakshmi Amankalu and Shashidhar from the Department of Applied Zoology.

The co-authors of the research work are Jagdish Gopal Paythankar (Net Deemed to be University), Mangeshwar Shrinath Baleja (Mangalore Institute of Oncology, Mangaluru), and Professor Rajashekar K. Patel (Mangalore University).

growing trend

Research work says that 6.8 million cases of IBD were reported in 2017. Over the past few decades, IBD has been the most prevalent in the Western world. However, recently, the incidence of IBD has increased rapidly in many Asian countries with a steady upward trend. Increased trends in the incidence of IBD and a lack of long-term treatment options are placing significant financial burdens on the health care system worldwide.

She said progress in research to understand the pathogenesis of IBD has been delayed by a lack of appropriate animal models. Drosophila or Drosophila, a genetic animal model, shares about 75% of sequence similarity with genes that cause various diseases in humans. In addition, the various combinations of genetic tools for regulating gene expression levels available in the fields of Drosophila research make them versatile genetic model organisms for various biological studies. Many features of digestion and absorption appear to be conserved among flies and mammals.

The team of researchers at the university modeled human intestinal colitis in Drosophila melanogaster using a different genetic and pharmacological approach. The highly valuable Drosophila colitis model can also be used to understand the molecular pathology of IBD and to screen various new drugs.

time consumption

Mr. Raghu . said Hindus Examination of drugs in a mouse model is very time consuming and there are certain ethical limitations to the use of mouse models. Screening new drugs in genetic models like Drosophila will facilitate scientific discoveries and consume less time. Hence the new flies model of the human colitis disorder will have a major impact on future studies on different gastrointestinal disorders.

“… In conclusion, the current study demonstrates that sodium dextran sulfate treatment in Drosophila melanogaster causes gut inflammation similar to that of enteritis in patients with IBD… However, Drosophila lacks adaptive immunity. But its structure Its genetics, distinct architecture, and similar physiology that resembles the digestive system of vertebrates make it useful. Importantly, Drosophila shares conserved signaling mechanisms for human gut physiology, making it a suitable model for studying inflammatory bowel disease.”

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